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Buffalo Bills vs. San Francisco 49ers

The Buffalo Bills and the San Francisco 49ers will both be gunning for a victory on Monday when they meet at State Farm Stadium.

Oddsmakers opened the Bills as -2.5-point favorites versus the 49ers, while the game's total opened at 48.

Last time out for San Francisco, they were a 23-20 winner as they battled the Rams on the road. The 49ers covered in the match as a +5-point underdog, while 43 combined points moved the game UNDER for totals bettors.

Buffalo was a 27-17 winner in its last match at home against the Chargers. They covered the -4-point spread as favorites, while the total score of 44 sent UNDER bettors to the payout window.

Buffalo:
Team record: 8-3 SU,6-5 ATS
Buffalo is 4-1 SU in its last 5 games
The total has gone OVER in 8 of Buffalo's last 11 games
Buffalo is 2-5 ATS in its last 7 games on the road

San Francisco:
Team record: 5-6 SU,5-6 ATS
The total has gone UNDER in 4 of San Francisco's last 6 games
San Francisco is 1-4 ATS in its last 5 games at home
San Francisco is 1-4 SU in its last 5 games at home

Next up:
Buffalo home to Pittsburgh Sunday, December 13
San Francisco home to Washington Sunday, December 13