nfl Matchup Report

September 21, 2025, 04:25 | Levi's Stadium
Arizona
Cardinals
2-0
vs
San Francisco
49ers
2-0
Odds
 
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Opening
Bovada
Westgate
Wynn
Arizona
San Francisco
Moneyline
+150 -180
+105 -125
   
   
Sep 21
4:25 PM
Spread
+3.5 -110 -3.5 -110
+1.5 -105 -1.5 -115
       
       
 
Total
47.5 o -115 u -105
44 o -110 u -110
Recent Form
Name Record ATS Offense Defense Diff ATS Home ATS Away OU Record OU Home OU Away
Arizona 2-0 1-1 23.50 17.50 6.00 0-1 1-0 1-1 1-0 0-1
San Francisco 2-0 2-0 21.50 17.00 4.50 0-0 2-0 1-1 0-0 1-1
Power Stats
Yards Per Point
Name Offense Defense Differential
ARI 13.37 20.04 -6.67
SF 18.35 16.27 2.08
Yards Per Pass
Name Offense Defense Differential
ARI 8.25 8.91 -0.66
SF 10.3 7.71 2.59
Yards Per Rush
Name Offense Defense Differential
ARI 4.34 3.75 0.59
SF 3.28 3.7 -0.42
Smart Chart
  • ARI
  • 20.67
  • 17.00
  • 3.67
  • 165.00
  • 111.33
  • 264.33
  • 76.33
  • -0.67
  • name
  • offense
  • defense
  • differential
  • passing yards
  • rush yards
  • passing yards allowed
  • rushing yards allowed
  • turnover differential
  • SF
  • 19.67
  • 16.33
  • 3.34
  • 271.33
  • 89.67
  • 162.00
  • 103.67
  • 0.33


Team Records
Arizona Cardinals
Name Record Home Away ATS ATS Home ATS Away Offense Defense Diff
Overall 2-0 1-0 1-0 1-1 0-1 1-0 23.50 17.50 6.00
Last 3 2-0 1-0 1-0 1-1 0-1 1-0 23.50 17.50 6.00
vs Conf 2-0 1-0 1-0 1-1 0-1 1-0 0.00 0.00 0.00
vs Div 0-0 0-0 0-0 0-0 0-0 0-0 0 0 0
San Francisco 49ers
Name Record Home Away ATS ATS Home ATS Away Offense Defense Diff
Overall 2-0 0-0 2-0 2-0 0-0 2-0 21.50 17.00 4.50
Last 3 2-0 0-0 2-0 2-0 0-0 2-0 21.50 17.00 4.50
vs Conf 2-0 0-0 2-0 2-0 0-0 2-0 8.50 6.50 2.00
vs Div 1-0 0-0 1-0 1-0 0-0 1-0 17.00 13.00 4.00
Supergrid
Title Stat Rank Stat Rank
Away Team Overall Scoring vs Home Team Overall Defense 23.50 11 17.00 8
Away Team Road Passing vs Home Team Home Passing Defense 130.00 24 0 0
Away Team Road Rushing vs Home Team Home Rushing Defense 146.00 5 0 0
Home Team Overall Scoring vs Away Team Overall Defense 21.50 19 17.50 10
Home Team Home Passing vs Away Team Road Passing Defense 0 0 208.00 14
Home Team Home Rushing vs Away Team Road Rushing Defense 0 0 107.00 15
Head To Head Summary
Name Record ATS OU Score Rush YPR PA CP PY TY TO +/-
Arizona 5-5 5-5 6-4 22.30 134.40 4.78 36.40 68.68 226.90 361.30 1.30
San Francisco 5-5 5-5 6-4 27.00 142.80 5.29 30.00 65.33 233.00 375.80 1.10
Head To Head Detail
Date Away Home Score Line Total OU Result ARY APY ATY ATT HRY HPY HTY HTT Away Team Attempts Home Team Attempts Away Team Completions Home Team Completions
Jan 5, 2025 SF ARI 24-47 138 298 436 3 151 242 393 0
Oct 6, 2024 ARI SF 24-23 169 189 358 1 153 231 384 3
Dec 17, 2023 SF ARI 45-29 144 262 406 0 234 202 436 2
Oct 1, 2023 ARI SF 16-35 105 257 362 0 124 271 395 0
Jan 8, 2023 ARI SF 13-38 61 194 255 4 169 142 311 0
Nov 21, 2022 SF ARI 38-10 159 228 387 0 67 247 314 2
Nov 7, 2021 ARI SF 31-17 163 274 437 0 39 298 337 3
Oct 10, 2021 SF ARI 10-17 152 186 338 1 94 210 304 1
Dec 26, 2020 SF ARI 20-12 227 171 398 1 120 230 350 2
Sep 13, 2020 ARI SF 24-20 180 224 404 1 123 243 366 0
Betting Odds Trends
San Francisco 49ers
San Francisco is 3-8 ATS in its last 11 games
San Francisco is 3-7 SU in its last 10 games
The total has gone OVER in 4 of San Francisco's last 5 games
San Francisco is 4-2 ATS in its last 6 games when playing Arizona
San Francisco is 5-9-1 ATS in its last 15 games when playing Arizona
San Francisco is 4-2 SU in its last 6 games when playing Arizona
The total has gone OVER in 6 of San Francisco's last 7 games when playing Arizona
San Francisco is 2-6-1 ATS in its last 9 games when playing at home against Arizona
San Francisco is 3-7 SU in its last 10 games when playing at home against Arizona
The total has gone OVER in 5 of San Francisco's last 7 games when playing at home against Arizona
San Francisco is 4-12 ATS in its last 16 games at home
San Francisco is 17-8 SU in its last 25 games at home
San Francisco is 2-5 SU in its last 7 games at home
Arizona Cardinals
Arizona is 9-4 ATS in its last 13 games
Arizona is 4-2 SU in its last 6 games
The total has gone OVER in 5 of Arizona's last 7 games
Arizona is 7-3 ATS in its last 10 games on the road
Arizona is 1-4 SU in its last 5 games on the road
The total has gone UNDER in 4 of Arizona's last 5 games on the road
Arizona is 2-4 ATS in its last 6 games when playing San Francisco
Arizona is 2-4 SU in its last 6 games when playing San Francisco
The total has gone OVER in 6 of Arizona's last 7 games when playing San Francisco
Arizona is 6-2-1 ATS in its last 9 games when playing on the road against San Francisco
Arizona is 7-3 SU in its last 10 games when playing on the road against San Francisco
The total has gone OVER in 5 of Arizona's last 7 games when playing on the road against San Francisco
Team Last 5 Games
Arizona Cardinals
Date Opponent score Result line ATS Result offensive rush yards offensive passing yards offensive total yards defensive rush yards defensive passing yards defensive total yards turnovers Location
Sep 14, 2025 CAR 27-22 W -7/45.5 L/O 82 211 293 49 303 352 -1 H
Sep 7, 2025 NO 20-13 W -5.5/44.5 W/U 146 130 276 107 208 315 0 A
Jan 5, 2025 SF 47-24 W -4.5/43 W/O 151 242 393 138 298 436 -3 H
Dec 28, 2024 LAR 9-13 L 6.5/48 W/U 113 283 396 68 189 257 2 A
Dec 22, 2024 CAR 30-36 L -5.5/47 L/O 206 176 382 243 149 392 2 A
San Francisco 49ers
Date Opponent score Result line ATS Result offensive rush yards offensive passing yards offensive total yards defensive rush yards defensive passing yards defensive total yards turnovers Location
Sep 14, 2025 NO 26-21 W -3/40.5 W/O 77 267 344 121 186 307 0 A
Sep 7, 2025 SEA 17-13 W -2.5/43.5 W/U 119 265 384 84 146 230 0 A
Jan 5, 2025 ARI 24-47 L 4.5/43 L/O 138 298 436 151 242 393 3 A
Dec 30, 2024 DET 34-40 L 3.5/50.5 L/O 75 400 475 152 287 439 2 H
Dec 22, 2024 MIA 17-29 L -2/44 L/O 81 293 374 166 215 381 1 A