San Francisco 49ers Game Logs
| event date | Opponent | Type | Result | score | ATS | Line | OU | Total | preview available | recap available |
|---|---|---|---|---|---|---|---|---|---|---|
| Aug 9, 2025 | vs Denver | PRE | L | 30-9 | L | 7 | O | 38.5 | No | Recap |
| Aug 16, 2025 | @ Las Vegas | PRE | W | 22-19 | W | 4.5 | O | 40 | No | Recap |
| Aug 23, 2025 | vs LA Chargers | PRE | W | 30-23 | W | 2.5 | O | 35.5 | No | Recap |
| Sep 7, 2025 | @ Seattle | REG | W | 17-13 | W | -2.5 | U | 43.5 | Preview | Recap |
| Sep 14, 2025 | @ New Orleans | REG | W | 26-21 | W | -3 | O | 40.5 | Preview | Recap |
| Sep 21, 2025 | vs Arizona | REG | W | 16-15 | L | -1.5 | U | 44.5 | Preview | Recap |
| Sep 28, 2025 | vs Jacksonville | REG | L | 26-21 | L | -3 | O | 46 | Preview | Recap |
| Oct 2, 2025 | @ LA Rams | REG | W | 26-23 | W | 8 | O | 43.5 | Preview | Recap |
| Oct 12, 2025 | @ Tampa Bay | REG | L | 30-19 | L | 3.5 | O | 46.5 | Preview | Recap |
| Oct 19, 2025 | vs Atlanta | REG | W | 20-10 | W | 1 | U | 46.5 | Preview | Recap |
| Oct 26, 2025 | @ Houston | REG | L | 26-15 | L | 3 | U | 41.5 | Preview | Recap |
| Nov 2, 2025 | @ NY Giants | REG | W | 34-24 | W | -2.5 | O | 47.5 | Preview | Recap |
| Nov 9, 2025 | vs LA Rams | REG | L | 42-26 | L | 6 | O | 49.5 | Preview | Recap |
| Nov 16, 2025 | @ Arizona | REG | W | 41-22 | W | -3.5 | O | 48.5 | Preview | Recap |
| Nov 24, 2025 | vs Carolina | REG | 0-0 | No | No | |||||
| Nov 30, 2025 | @ Cleveland | REG | 0-0 | No | No | |||||
| Dec 14, 2025 | vs Tennessee | REG | 0-0 | No | No | |||||
| Dec 22, 2025 | @ Indianapolis | REG | 0-0 | No | No | |||||
| Dec 28, 2025 | vs Chicago | REG | 0-0 | No | No | |||||
| Jan 4, 2026 | vs Seattle | REG | 0-0 | No | No |